Rams boss Nigel Clough makes one change to the side that suffered the narrow 2-0 defeat at the Reebok Stadium against Bolton Wanderers on Tuesday night.
17-year-old midfielder Will Hughes is recalled to the line-up, replacing former Reading striker Nathan Tyson, who drops to the substitutes' bench.
Elsewhere, new signing Kieron Freeman is named on the bench after completing his move from fierce rivals Nottingham Forest earlier this week.
Defender Jake Buxton continues to miss out through illness, whilst striker Theo Robinson is recalled to the bench after scoring in the Under-21s' midweek 2-2 draw with Leeds United.
Conor Sammon starts his second competitive fixture for the Rams following his recent move from Premier League side Wigan Athletic - and starts alongside Northern Ireland international Jamie Ward in attack.
Derby County: Fielding (GK); Brayford, Keogh, O'Connor, Roberts; Coutts, Hendrick, Bryson, Hughes; Ward, Sammon.
Subs: Legzdins (GK), Tyson, Jacobs, Doyle, Gjokaj, Freeman, Robinson.
Wolverhampton Wanderers: Ikeme (GK); Zubar, Berra, Johnson, Ward; Peszko, Edwards, Davis, Doumbia; Doyle, Ebanks-Blake.
Subs: De Vries (GK), Elokobi, Stearman, Sigurdason, Nouble, Jonsson, Forde.