Manager Frank Lampard has made one change to the side which beat Swansea City 2-1 at Pride Park Stadium last week.
Jack Marriott returns to the starting line-up after recovering from the bruised foot he sustained against Stoke City and he has replaced David Nugent in attack.
Harry Wilson will hope to continue his fine form in front of goal as he starts alongside Mason Mount and Tom Lawrence.
The Welshman has scored four goals in his last three games and currently tops the scoring charts for Derby.
Here are the teams:
Wigan Athletic: Walton, Morsy (C), Burn, Kipre, Evans, James, Naismith, Byrne, Roberts, Windass, Vaughan.
Substitutes: Jones, Bruce, Connolly, Gibson, McManaman, Garner, Grigg.
Derby County: Carson, Bogle, Keogh (C), Tomori, Malone, Bryson, Huddlestone, Mount, Lawrence, Wilson, Marriott.
Substitutes: Roos, Pearce, Macdonald, Holmes, Jozefzoon, Waghorn, Nugent.
